Friday, May 8, 2009

1&1 Makes 50 percent Price Reductions Across Product Lines

1and1 PROMO


(WEB HOST INDUSTRY REVIEW) -- The first full week of May had a number of significant promotions such as LCN.com's 40 percent off sale on high-end shared hosting and 1&1 Internet offering 50 percent off all its product lines.

PowerDNN Unveils First Summer Promo

DotNetNuke-based hosting and solutions provider PowerDNN (www.powerdnn.com) began rolling out a series of promotions May 4 which will continue throughout the summer. The initial promotion, is its "Power 1 Enterprise" dedicated server with a dual core box, 160 Gb RAID 1 hard drives, and 4 Gb of RAM all for $450 per month. The package also includes features such as disaster recovery, advanced monitoring, and SmarterMail Pro.

LCN.com Offers May Savings On Top Web Hosting Package

Until the end of May, UK registrar and web host LCN.com (www.lcn.com) is offering a 40 percent discount off the regular price of its high-end "Dynamic Hosting" package. New customers can purchasing the shared hosting package for only £30 (or $42) per month for up to a year-long contract. Existing LCN.com customers are also being given the opportunity to upgrade their current packages to Dynamic Hosting at no charge.

1&1 Makes 50 percent Price Reductions Across Product Lines

Web host 1&1 Internet (www.1and1.com) is holding a promotion providing 50 per cent or more off the first six months across its very wide range of products including all its web hosting packages, dedicated, managed and virtual servers as well as eShops, which are only £2.49 (about $3.75) per month plus VAT for the first six months. The promotion is in effect until 30 June 2009.

BlackSun Offers $7.99 Per Month Hosting

Canadian web host BlackSun (www.blacksun.ca) has announced changes to its pricing structure for domain and web hosting plans, offering new and existing clients hosting for as little as $7.99 per month on a multi-year plan.

Source: http://www.thewhir.com/web-hosting-news/050809_Web_Hosting_Sales_and_Promos_Roundup

Thursday, February 26, 2009

Rocky Mountain News promises 'spectacular' finale

DENVER (AP) — The Rocky Mountain News will say goodbye to Colorado on Friday, and the boss promises the last edition will be a doozy.

"It's going to be spectacular," John Temple said with a smile Thursday, hours after owner E.W. Scripps Co. announced it would close the newspaper because of mounting losses.

"It's very rare that you get to play the music at your own funeral, so you want to make sure you do it well," said Temple, the newspaper's editor, publisher and president.

"I want to play something that you can listen to for years to come," he said.

Managing Editor Deb Goken said the last edition will include a 52-page special section on the newspaper's history with "Goodbye Colorado" as the headline.

The regular newspaper will be inside the wraparound commemorative edition.

Goken said the press run would be 350,000. The newspaper's normal weekday circulation is around 210,000.


Feb. 26 (Bloomberg) -- The Rocky Mountain News, Colorado’s oldest newspaper, will put out its final edition tomorrow after publisher E.W. Scripps Co. failed to find a buyer.

Scripps began seeking offers for the 150-year-old Denver daily in December after declining advertising sales made the publication its only unprofitable newspaper. Shutting down the Rocky, which lost $16 million last year, leaves the Denver Post as the city’s only major newspaper.

The closure signals other publishers seeking to sell newspapers, including Hearst Corp. and Gannett Co., may have difficulty finding buyers. Hearst and Gannett said they may shut down their respective San Francisco Chronicle and Tucson Citizen, in Arizona, if they can’t sell the publications.

“This is not a good time to try to sell a newspaper,” said John Morton, president of Morton Research Inc. in Silver Spring, Maryland. “This deep recession for newspapers doesn’t make these particularly compelling properties to buyers.”

Scripps, based in Cincinnati, will turn over its 50 percent stake in an eight-year-old joint operating agreement with MediaNews Group Inc., owner the Denver Post. Scripps, which bought the Rocky in 1926, had attempted to sell the stake along with the newspaper.

Employees will remain on the payroll until April 28, Scripps said. The Rocky Mountain News won four Pulitzer Prizes in the past decade, according to a statement on its Web site.

San Francisco Chronicle

Tim King, a Scripps spokesman, wasn’t immediately available for comment.

The only party to express interest didn’t make a strong enough offer, Scripps said in a statement today. The deadline for submissions expired in mid-January.

Hearst said Feb. 24 it may close the San Francisco Chronicle if it can’t find a buyer “within weeks” and said last month it may shutter the Seattle Post-Intelligencer or turn it into a Web- only operation if it’s not sold by March. Gannett set a March 21 deadline to unload the Tucson Citizen.

Scripps dropped 10 cents to $1.08 at 2:30 p.m. in New York Stock Exchange composite trading. The shares had fallen 47 percent this year before today.


Source:
http://www.google.com/hostednews/ap/article/ALeqM5h09UKeBLvq76fWMH69PoOhfXB51AD96JISVG0
http://www.bloomberg.com/apps/news?pid=20601103&sid=aJ.XFQ14Qu9M&refer=us

Monday, February 23, 2009

Jennifer Aniston/ Angelina Jolie Fight

Oscars Really Wanted That Jennifer Aniston/ Angelina Jolie Fight


Buzz up!Like this story?
Then buzz it up

February 23rd, 2009 at 11:00 by Stuart Heritage

The Oscars, while ostensibly about giving little statues to humourless men, were only really about one thing.

That’s right - Jennifer Aniston and Angelina Jolie. Last night’s Oscars marked the first time that Jennifer Aniston and Angelina Jolie had come within punching distance of one another for years.

They didn’t fight, but at least the Oscars producers tried their hardest. As Jennifer Aniston walked on stage, they instantly cut to a close-up of Angelina Jolie’s face. Then they told her that Jennifer thinks her Mum’s a slag before chanting the word ’scrap’ until Hugh Jackman got excited and passed out. We heard.

Forget all the hoo-ha about Slumdog Millionaire and Sean Penn and Hugh Jackman, because there was only one way to watch the Oscars popular this year - a full-on, hair-pulling, eye-gouging, vaguely-lesbian catfight between Jennifer Aniston and Angelina Jolie on the Oscars red carpet.

And it could have happened, too - as we’ve already reported, last night’s Oscars saw Jennifer Aniston and Angelina Jolie forced together in a way not seen since we read some disturbingly specialist fan fiction about them the other week.

Would Jennifer Aniston still be so filled with bitterness about her divorce from Brad Pitt that she’d fling herself at Angelina Jolie on the Oscars red carpet and start punching away? Would Angelina Jolie respond by turning her arm into a Terminator-style metal spike and pushing it through Jennifer Aniston’s skull? Literally about 12 people on the internet were breathless with anticipation.

However, while the long-awaited physical fight between Jennifer Aniston and Angelina Jolie didn’t transpire at the Oscars, that didn’t stop the producers from doing their best to give the people what they want. Last night, Jennifer got to introduce a segment with Jack Black and - as Oscars segment-introduction tradition dictates - Jennifer Aniston was nervous, stilted, awkward and unfunny for the duration of it.

So what one thing could compound Jennifer Aniston’s fear even further during her time on stage? That’s right, multiple close-ups of Angelina Jolie’s great big face. Fox News reports:

Oscar telecast producers panned to Brad and Angelina not once, but twice, as a visibly nervous Aniston did her schtick. In the first pan to Brangelina, Jolie was gamely guffawing as Aniston, whom Pitt left in 2005 in order to be with Jolie, hammed it up. In the second pan, the couple looked on with the bemused half-grins we’ve come to know from literally thousands of paparazzi pics over the past three years.

Depending on who you are, Angelina Jolie’s cutaway reactions to Jennifer Aniston will mean completely different things. Team Jolie will praise Angelina for smiling at Jennifer with grace and dignity, while team Aniston will think that Angelina was laughing at Jennifer’s discomfort like some sort of awful witch.

The truth? Nobody knows. What we do know, though, is that if producers really wanted to turn the Oscars into an episode of Jerry Springer, then they really needed to put a little triangle in the corner of the screen reading ‘Hey bitch, I stole your husband and we both think you’re an asshole’ while a podgy redneck whoops and takes his shirt off. And they didn’t even invite Tim Allen to the show as far as we know. A trick missed, Oscars, a trick missed.

Source: http://www.hecklerspray.com/oscars-really-wanted-that-jennifer-aniston-angelina-jolie-fight/200921109.php

Monday, October 6, 2008

Samsung Sway SCH-u650 on Verizon


Verizon Wireless today unveiled a new slim slider phone designed for them by Samsung. It is called the Samsung Sway and you’ll find it pricing around $70 after rebate and contract.

The Samsung Sway offers your typical array of media and lifestyle features to make it more than just a mobile. It includes being a MP3 player which can be loaded with music via a USB cable, a 2.0-megapixel digital camera with video recording and digital zoom and Bluetooth support.

Other features of the Sway include expandable memory up to 8GB via microSD, a bilingual user interface, a weight of only 3.56 ounces and chat time of up to 270 minutes. It will be available later this month.

As we know Nokia is the number one selling phone maker and the No.2 spot had been taken up by Motorola, however Samsung has now taken it away from them. It is because of phones like the upcoming Samsung Sway SCH-u650, which has helped the Korean electronics giant reach this success.

The new Samsung Sway SCH-u650 will be available on the Verizon carrier on October 14. The handset is a slider phone and has a brushed steel finish. The camera is nothing special, just 2-megapixel, but does come with NightShot mode.

The Samsung Sway takes the microSD card up to 8GB; the phone has a standby time of 321 hours and 270 minutes talktime. The Samsung Sway will cost $69399 after a mail-in $50 rebate with Verizon.

Wednesday, September 24, 2008

Knight Industries Three Thousand (KITT)


KITT is back! But like almost everyone else on TV these days, the star of the revived "Knight Rider" has had a little work done. He's still KITT, but that now stands for Knight Industries Three Thousand. And instead of the classic Pontiac Firebird Trans Am, he's now a Ford Mustang Shelby GT500KR with nanotechnology and the ability to take on the temporary appearance of other cars.

Though KITT may be the most recognizable name and grill from TV's recent past, he's not alone. They may not ever grab the cover of Rolling Stone or TV Guide, but these TV star cars have charisma to spare.

The new KITT is one cranky back-seat driver.

The reboot of the kitschy ’80s action show “Knight Rider” (premiering Wednesday night at 8 on WHDH, Ch. 7) comes with some solid CGI work, a few pretty people and an annoying spin on the retooled vehicle.

The new KITT (Knight Industries Three Thousand) is one cool car, and in this age of big-screen “Transformers,” it better be. KITT is capable of morphing into just about any vehicle. It possesses the weaponry of a jet fighter and an artificial intelligence so great it borders on psychic.

The plot in the opener - no, really, I’m being generous - centers on a missing package, the villainous agents out to get it and our hero - and nominal driver - Michael’s (Justin Bruening, “All My Children”) inability to recall several years of his life, including one significant marriage proposal.

The espionage is just a front to show the car in action. After being blasted with a chemical weapon, the vehicle races down highways aflame, hitting speeds of over 330 mph.

In another brazen stunt, the vehicle morphs from a truck to its natural “turbo charge” self and shifts Michael and fellow agent Sarah (Deanna Russo) from the truck’s bed to the front seats.

That’s power steering.

At first, Michael and KITT’s bantering is humorous, in a Picard-Data kind of way.

“Keep your eyes peeled, KITT,” Michael says.

“Michael, I do not have eyes,” KITT replies.

There’s an hour of this, and KITT gets twice as much dialogue as anyone else. He scolds Michael about his diet, his drinking and his sex life. He embarrasses him about his connection to Sarah. He corrects him about his knowledge of classified information.

Other than Michael and Sarah, the humans here have about as much to do as a car freshener. Knight Industries leader Alex Torres (Yancey Arias) might be evil. Technician Billy Morgan (Paul Campbell) is the geek you’d expect him to be. Office administrator Zoe (Smith Cho) seems to be a Valley Girl stereotype.

Kids are going to want to watch this, but parents must consider the violence. In one segment, though not explicit, a woman cuts off a man’s thumb.

Val Kilmer voices the role as if he were playing “2001: A Space Odyssey’s” HAL 9000, but it’s easy to imagine the same dialogue being handed to Doris Roberts’ overbearing mother from “Everybody Loves Raymond.”

Is anyone’s need for speed so great that they’d put up with such a relentless nag?

Wednesday, September 10, 2008

September 11, 2001 to September 11, 2008


New York to observe seventh anniversary of 9/11 attacks
Seven years after the Sep 11 terrorist strikes, New Yorkers Thursday will remember the attacks that killed more than 2,700 people with the destruction of the World Trade Center's twin towers.

The city will observe the anniversary with renewed calls for vigilance against the constant threats of new terrorist attacks. Names of the dead will be read yet again.

The presidential nominees of both US major parties, Republican senator John McCain and his rival, Democratic senator Barack Obama, plan to attend ceremonies at Ground Zero, site of the destroyed towers.

Both candidates have agreed to call off their election rhetoric and suspend campaign television ads on that day out of respect for the dead from the 9/11 attacks, which targeted New York and Washington.

McCain and Obama issued a joint statement this week: "All of us came together on 9/11 - not as Democrats or Republicans but as Americans. We were united as one American family. On Thursday, we will put aside politics and come together to renew that unity."

The emphasis on the seventh anniversary has shifted to educating new generations about terrorist threats and the way families of victims survive the loss of loved ones.

The National Sept 11 Memorial and Museum this week unveiled programmes for classroom remembrances, distributed to selected schools across the United States. The outreach scheme will identify teachers to work in partnership with the memorial foundation to teach in classrooms about the attacks on September tember 11, 2001.

The memorial - for the nearly 3,000 victims of the 2001 terrorist attacks against New York and the Pentagon defence headquarters outside Washington, plus the prelude attack of the 1993 the World Trade Center truck bombing - is being built at Ground Zero, site of the original towers.

The memorial, designed and created by Michael Arad and Peter Walker, consists of two pools resting on the original two footprints of the 100-storey twin towers, which collapsed soon after being struck by hijacked airliners on September 11.

But construction costs have soared to nearly $1 billion, forcing several reviews of the plan and delay in the construction of the memorial.

Sonnet Takahisa, education director for the Memorial and Museum, said: "The record of the events of Sep 11, the significance of those events, and our understanding of their impact are still evolving. We know that teachers feel ill-prepared to address 9/11 in
their classrooms, and we hope to provide resources for teachers to use that will encourage and facilitate discussion."

Among material offered for classroom remembrances are documentaries recounting the events of 9/11 from the perspectives of family members, survivors and rescue workers.

US classrooms currently have no formal curriculum on 9/11.

The new World Trade Center, also besieged by soaring construction costs and constant reviews to make it an attack-proof fortress, will not be completed until after 2011, two years later than originally planned.

A Freedom Tower will adorn the center at 1,776 feet, a height chosen to recall the US Declaration of Independence of 1776.

The 9/11 attacks killed more than 2,700 people in New York, including 300 firefighters and police trapped after rushing into the towers to save the thousands of people working inside. The trauma has lingered with thousands of New Yorkers who lost friends or relatives or who continued to suffer mentally or physically.

New York City Mayor Michael Bloomberg recently launched a programme to reach out to New Yorkers who still suffer health problems related to the terrorist attacks, with ads spanning television, radio and print media. The programme is part of a $5 million campaign to provide free health care to those who need help.



List of September 11th events



In addition to the ceremony at Ground Zero, here is a sampling of events on Thursday marking the seventh anniversary of the Sept. 11 attacks.

Point Lookout: 7:30 a.m., Town of Hempstead memorial ceremony, Point Lookout Beach, Lido Boulevard.

Rockville Centre: 7:45 a.m., memorial Mass celebrated by Bishop William Murphy, St. Agnes Cathedral, 29 Quealy Place.

Fire Island: 8-9:30 a.m., "Lonelyville to the Lighthouse Walk for Peace," Plank Walk, Lonelyville to Fire Island Lighthouse.

Share your thoughts about Sept. 11, 2001, and the ensuing five years.

If the media would stop giving this attention, maybe the 9/11 families could start spending the millions of dollars given to them, and stop costing the city and country millions more in construction delays.

Everyday we do not build they have won. It is time to for the families to accept what has happened and move on. Would those you are grieving about want it this way? Or would they want to show the terrorists that nothing can keep the USA Down. Let us all let them build a bigger better New York.


Albertson: 8:30 a.m., Town of North Hempstead ceremonies, Clark Botanic Garden, 193 I.U. Willets Rd.

Bellport: 8:30 a.m. and 12:30 p.m., wreath-laying ceremony honoring Eastern Suffolk BOCES alumnus Glen Pettit, police officer killed on Sept. 11, Brookhaven Technical Center, 350 Martha Ave.

Manhattan: 10 a.m.-7 p.m., public invited to sign steel beams to be used in construction of National September 11 Memorial and Museum, Battery Place, Greenwich and Washington streets.

Oakdale: 10 a.m.-11 a.m., remembrance ceremony at outdoor memorial garden by Connetquot students, faculty and administrators and local elected officials, Idle Hour Elementary School, 334 Idle Hour Blvd.

Manhattan: 11 a.m., 3 p.m., screening of documentary, "In Memoriam: New York City, 9/11/01," Museum of the City of New York, 1220 Fifth Ave., free with museum admission, $9 adults, $5 seniors and children. 212-534-1672, ext. 3395.

Mineola: 11:30 a.m., Nassau County Court System ceremony honoring Sept. 11 victims, with Court Officer Sgt. Frank Barry, a first responder on 9/11, to speak, Nassau County Supreme Court, central jury courtroom, first floor, 100 Supreme Court Dr.

Hempstead: 1 p.m., memorial service hosted by Hempstead Village Mayor Wayne Hall and the board of trustees, with the Hempstead High School choir, Denton Green (across from Village Hall), 99 Nichols Ct.

Central Islip: 5 p.m., memorial service, including reading of the names of 456 Long Islanders who died at the World Trade Center, followed by 6:35 p.m. game between the Long Island Ducks and the Somerset Patriots, Citibank Park, 631-940-3825.

Manhattan: 5 p.m., memorial service led by Archbishop Demetrios of the Greek Orthodox Archdiocese of America, at the site of St. Nicholas Greek Orthodox Church, which was destroyed in the collapse of the South Tower, corner of Greenwich and Liberty streets.

Lynbrook: 6 p.m., memorial service, 9/11 Memorial Park, Lynbrook Village Hall, 1 Columbus Dr., 516-599-8300.

Freeport: 6 p.m., American Legion ceremonies on the "Miss Freeport," docked at Woodcleft Canal.

Commack: 6:30 p.m., candlelight ceremony honoring two Commack High School graduates who died at the World Trade Center. Commack High School, 1 Scholar Lane.

Seaford: 7 p.m., tribute to five Seaford High School graduates who died at the World Trade Center, Seaford High School, 1575 Seamans Neck Rd.

Manhattan: 7 p.m., "Hands Across The Sea," a special concert by the Oriel Choir of Oxford University, England, in tribute to victims and rescue workers. Soldiers', Sailors', Marines', Coast Guard and Airmen's Club, 283 Lexington Ave., between 36th and 37th streets.

Manhattan: 7:30 p.m., Concert for Peace, including U.S. premiere of "Iraqi Requiem" by Mohammed Amin Ezzat, Merkin Concert Hall, 129 W. 67th St., $35-$125, 212-501-3330.

Tuesday, September 2, 2008

Amantadine and Huntington's disease

Amantadine and Huntington's disease


Medication and Treatment for Huntington's disease


Susceptibility to Oseltamivir and Amantadine of Human Influenza Viruses Circulating in Portugal

Background:
Since 2002, increasing incidence of amantadine resistance has been detected worldwide. In a minor extent, emergence of oseltamivir-resistant strains has been identified during 2007/2008 winter season.
This study aims to contribute to global surveillance on antiviral resistance and to risk assessment of drug use with continuous liberation of national data. Its main objective is to evaluate influenza virus susceptibility to oseltamivir and amantadine during 2004/2005-2007/2008, in Portugal.

Methods:
Susceptibility to oseltamivir was evaluated by fluorescence assay in 233 strains from 2004/2005-2007/2008. NA and HA1 gene sequencing was performed in statistical outliers and in 30% of susceptible strains, identified by fluorescence.
Resistance to amantadine was evaluated by pyrosequencing in 128 strains from 2004/2005-2006/2007.

Results:
All 89 A(H3N2) and 94 B influenza strains tested shown to be oseltamivir-susceptible. Of the 50 A(H1N1) strains tested, 3 of the 14 from 2007/2008 were drug-resistant by exhibiting fluorescence-IC50 values approximately 400 times higher than the median value and mutation H274Y in NA sequence.
Susceptibility to amantadine was detected in all 23 A(H1N1) strains tested. Resistance was found, by identification of mutation S31N in M2 sequence, in 24 of the 105 A(H3N2) strains tested: in the single strain from 2005/2006 and in 23 of the 35 strains from 2006/2007.

Discussion:
The origin of oseltamivir-resistant A(H1N1) strains in Portugal (2007/2008), and concurrently in other European countries, remains unclear. Their persistence through influenza seasons and their effect in viral evolution could become clearer with subsequent and continuous data analysis. Conversely, emergence of amantadine resistance in Portugal, identified in 2005/2006 and persistent through 2006/2007, probably derived from global spread of A(H3N2) virus bearing mutation S31N.

These preliminary findings can presently contribute to monitor international dispersion of resistant viruses. Continuous and timely input of national data onto global surveillance constitutes the basis for risk assessment on antiviral drug use.

Author(s): V. Correia, H. Rebelo-de-Andrade, L. Santos, M. Gíria
Affiliation: Centro Nacional da Gripe, Instituto Nacional de Saúde (Research grant supported by Calouste Gulbenkian Foundation - Portugal), Lisboa, Portugal


Source: http://www.setbb.com/phpbb/viewtopic.php?mforum=fluwiki2&p=1078#1078


The U.S. Food and Drug Administration (FDA) has approved Xenazine (tetrabenazine) for the treatment of chorea in people with Huntington’s disease. Chorea is the jerky, involuntary movement that occurs in people with this disease.

Xenazine is the first medication of any kind approved in the U.S. by the FDA for the treatment of any symptom of Huntington’s disease. According to the FDA, “Serious side effects reported with use of Xenazine include depression and suicidal thoughts and actions.”

Huntington's disease, which affects about 30,000 people in the U.S., is a rare, inherited neurological disorder that causes degeneration of brain cells. The deterioration of brain cells causes the uncontrolled movements, loss of intellectual powers, and emotional difficulties. Huntington’s disease is passed from parent to child and each child of a parent with the disease has a 50% chance of inheriting the condition.

Huntington’s disease is an autosomal dominant inherited disorder characterized by a triad of motor, cognitive, and psychopathological symptoms (1). Currently, the only treatment options available for the disease are symptomatic. Aripiprazole is a novel antipsychotic drug that possesses the pharmacological characteristics of a partial agonist of the dopamine D2 and serotonin 5-HT1A receptors and antagonist of the 5-HT2A receptor. We report the use of aripiprazole in the treatment of psychotic symptoms in a patient with Huntington’s disease whose diagnosis was confirmed by DNA analysis.